Vriligy 60mg (dapoxetine 60mg) are used to treat premature ejaculation (PE), which is one of the most common causes of sexual dysfunction in men. It is defined as early ejaculation with minimal sexual stimulation before or soon after penetration, and can cause distress and problems with relationships. Vriligy is used to improve control over ejaculation and increase the time interval before ejaculation occurs during intercourse, for men with persistent or recurrent PE.
How does Vriligy work?
Vriligy tablets 60mg contain dapoxetine 60mg, a selective serotonin reuptake inhibitor (SSRI) that is used specifically for premature ejaculation (PE), as it has a rapid onset of action, with maximum effect within 1-2 hours and a short half-life, which means that it is rapidly eliminated from the body within 24 hours. Ejaculation is a reflex that is mediated by the sympathetic nervous system. When sexual stimulation has reached a certain threshold, sensory nerve cells in the spinal cord are activated and nerve impulses are sent to the brain, which then send messages back to motor neurones controlling the muscles in the penis that contract to effect ejaculation. The ejaculation reflex is thought to be mediated by serotonin, a specific brain chemical or neurotransmitter that is involved is transmitting nerve signals, which enables brain cells to communicate. Low levels of serotonin in certain areas of the brain are thought to be responsible for causing PE. Dapoxetine in Vriligy blocks the reuptake of serotonin from the synapse, which is the gap between nerve cells across which chemical messages are sent from one nerve cell to another. If the re-uptake of serotonin by the first nerve cell (pre-synaptic) is blocked, this means that there is more serotonin remaining for the receiving nerve cell (post-synaptic), which allows nerve cells to communicate with each other for longer. This action of dapoxetine in Vriligy 60 helps prolong the ability to maintain sexual activity without premature ejaculation and maintain control over ejaculation for longer.
What does Vriligy contain?
Vriligy tablets 60mg contain active ingredient dapoxetine, a selective serotonin reuptake inhibitor (SSRI) that is used to treat and prevent persistent or recurrent premature ejaculation (PE). They also contain : lactose, cellulose-microcrystalline, croscarmellose sodium, silica-colloidal anhydrous, magnesium stearate, hypromellose, titanium dioxide, iron oxide black, iron oxide yellow.
What are the side effects of Vriligy?
The most commonly reported side effects when taking Vriligy tablets60mg include, headache, gastrointestinal upset (nausea, diarrhoea, dry mouth, abdominal discomfort), dizziness, drowsiness, tremor, difficulty sleeping, increased blood pressure, erectile dysfunction, reduced libido.
What medications interact with Vriligy?
Several medications interact with Vriligy tablets 60mg and should either not be taken while you are taking Vriligy or only after discussion and instruction from your doctor:
Drugs that cause a serious reaction with Vriligy: monoamine oxidase inhibitors for depression, thioridazine for schizophrenia, the anticoagulant warfarin increases risk of bleeding, NSAIDs like aspirin or ibuprofen St. John´s Wort, migraine medicines like sumatriptan, the analgesic tramadol, SSRI antidepressants like paroxetine or citalopram, SNRI antidepressants like venlafaxine, lithium for mood disorders,
Drugs that affect Vriligy: thioridazine for schizophrenia, antifungals like ketoconazole, antibiotics like erythromycin, HIV treatments like ritonavir and atazanavir, calcium channel blockers like diltiazem for hypertension
How should Vriligy be taken?
You should take your Vriligy tablets 60mg swallowed whole with a glass of water with or without food. You should take your Vriligy tablet 1-3 hours before planned sexual activity. You should not take more than one tablet in 24 hours and avoid alcohol.
